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Hollow microsphere
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10 Metric Ton (MOQ)
Hollow microspheres (microballoons), loaded with drug in their outer polymer shells, were prepared by a novel emulsion-solvent diffusion method. The ethanol:dichloromethane solution of drug (tranilast or ibuprofen) and an enteric acrylic polymer were poured into an agitated aqueous solution of polyvinyl alcohol that was thermally controlled at 40 degrees C. The gas phase generated in the dispersed polymer droplet by the evaporation of dichloromethane formed an internal cavity in the microsphere of the polymer with the drug. The drugs incorporated in the solidified shell of the polymer were found to be partially or completely amorphous. The flowability and packability of the resultant microballoons were much improved compared with the raw crystals of drug. The microballoons floated continuously over the surface of acidic dissolution media containing surfactant for greater than 12 h in vitro. The drug release behavior of the microballoons was characterized as an enteric property, and drug release rates were drastically reduced depending on the polymer concentration at pH 6.8.
Hollow Bubbles
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Hollow bubbles are nano particles having size between 10 to 300 micron & hard surface shell with Alumino & silicate contains. They characteristics like hire consisting strength free flowing, and lower density. Indiacenosphere is a leading Exporter, Manufacturer & Supplier of Hollow Bubbles. We have great expertise in manufacturing string of Hollow Bubbles. It is just a fraction of the density of resins. In weight, it takes little addition of Hollow Spheres to displace heavy materials. Simultaneously they reduce density and add volume. If buoyancy is a only criteria, than Potters Hollow Spheres is unbeatable in any standards. In addition they also saves material costs; microspheres are just a fraction of cost of resins as far as volume is concerned.
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