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Proguanil (chloroguanide) is a biguanide; a synthetic derivative of pyrimidine. It was developed in 1945 by a british antimalarial research group. It has many mechanisms of action but primarily is mediated through conversion to the active metabolite cycloguanil. This inhibits the malarial dihydrofolate reductase enzyme. Its most prominent effect is on the primary tissue stages of p. Falciparum, p. Vivax and p. Ovale. It has no known effect against hypnozoites therefore is not used in the prevention of relapse. It has a weak blood schizonticidal activity and is not recommended for therapy of acute infection. However it is useful in prophylaxis when combined with atovaquone or chloroquine (in areas where there is no chloroquine resistance). 3 mgkg is the advised dosage per day, (hence approximate adult dosage is 200 mg). The pharmacokinetic profile of the drugs indicates that a half dose, twice daily maintains the plasma levels with a greater level of consistency, thus giving a greater level of protection. The proguanil- chloroquine combination does not provide effective protection against resistant strains of p. Falciparum.
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Proguanil Hydrochloride 100mg Tablet 10*10 ALU
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100 Box (MOQ)
Associated with the class Antiprotozoals, it allows to manage infection occurred in red blood cells and is carried out through mosquito bites. This medicine is a blend of two combinations namely Atovaquone and Proguanil. One is advised to take an entire course of medicine for better and adequate results. Nicolan Healthcare Pvt Ltd is the fastest-growing pharmaceutical company that administrates worldwide medicinal demands and works accordingly.
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Proguanil (also known as chlorguanide and chloroguanide) is a prophylactic antimalarial drug. It was the first antifolate antimalarial drug ever developed, with initial reports of its efficacy dating back to 1945. Currently it remains effective for prevention of infection from Plasmodium falciparum malaria, as well as treatment in someone who has already become infected by the parasite.
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We as a Manufacturer, Supplier and Exporter of Proguanil HCL take pleasure in being the one stop solution for our customers. For our customers, we make it available in different specifications to match their demands. It is anti-malarial, safe to use and free from impurities as it is made of first-rate raw material. It is treasured for its quality round the world. The quality control team on staff keeps a close eye on strict concurrence with industrial quality standards.
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We are the leading Exporter of Proguanil Hydrochloride in India. Proguanil Hydrochloride control and cure Malaria caused by mosquito bites. Proguanil Hydrochloride contains in Malarone tablets works in two different ways to stop any malarial parasites that have entered the blood or the liver from reproducing and increasing in numbers. The Molecular weight is 290.19 g/mol.and melts at 241 -to 244ºC. We deal with Proguanil Hydrochloride in all major Pharma industries. Proguanil Hydrochloride, proguanil hydrochloride uses, proguanil, hydrochloride, buy proguanil, buy hydrochloride, hydrochloride hcl, Proguanil hcl, chemicals, chemical products, organic chemicals, Active Pharmaceutical Ingredients,Antimalarials,Chlorides,Hydrochlorides, Plasmodium Falciparum,Plasmodium Falciparum Malaria
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