Imipenem and Cilastatin Injection
Wide spectrum action against aerobes & anaerobes More active than ceftazidime Wide spectrum of action including gram +ve & gram-ye coverage Cilastatin diminishes adverse reaction associated with imipenem administration Dosage : Adults : In terms of Impenem ,1.2 g Daily in Divided Doses every 6-8 Irs given Via I.V. infusion Children : 3WS 15-25 mg/Kg Every 6 Hrs by IV Infusion Surgical Prophylaxis In Terms of Impenem 19 given on induction of anaesthesia followed by 1g 3 Hrs Later Indications : Infections In Dialysis Patients UT Infections LRT Infections Endocarditis Gynaecological Infection Diabetic Foot Infection Intra Abdominal Infection Bone & Joint Infections Skin & Skin Structure Infection Nosocomial Infections