Name: Metformin Hydrochloride Prolonged Release Tablets I.P.
Form: Oral Tablet (Prolonged / Extended Release) Strengths Available: Commonly 500 mg, 750 mg, or 1000 mg Drug Class: Biguanide (Oral Antidiabetic Agent)
🔹 Description:
Metformin Hydrochloride Prolonged Release Tablets are used for the management of Type 2 Diabetes Mellitus. The prolonged release formulation allows gradual absorption, reducing gastrointestinal side effects and providing stable blood sugar control over a longer duration.
🔹 Indications:
Type 2 Diabetes Mellitus (non-insulin-dependent diabetes)
May be used alone or in combination with other antidiabetic agents (e.g., sulfonylureas, insulin)
🔹 Mechanism of Action:
Metformin:
Decreases hepatic glucose production
Reduces intestinal glucose absorption
Improves insulin sensitivity
It does not cause hypoglycemia when used alone.
🔹 Dosage:
Usually taken once daily with the evening meal
Starting dose: 500 mg once daily, may be increased gradually
Do not crush or chew prolonged-release tablets
🔹 Common Side Effects:
Nausea
Diarrhea
Abdominal discomfort
Flatulence
Metallic taste
These are less common with prolonged-release formulations compared to immediate-release.
🔹 Precautions & Warnings:
Â
Lactic acidosis (rare but serious) – monitor renal function before and during treatment
Not recommended in:
Patients with severe kidney or liver disease
Alcohol abuse
Severe infection, surgery, or conditions leading to hypoxia
Temporarily discontinue before procedures involving IV contrast
Post Free Ad
www