Domperidone :
Proton-Pump (H+K+ ATPase) inhibitor.
Produces long duration of action for 24 hours due to prolonged binding to the enzyme.
Esomeprazole :
Prokinetic & Anti Emetic agents.
Enhances gastroduodenal peristaltic activity.
Stimulates tone of Lower esophageal Sphincter (LES)