TreatmentReatment And Suppression Of Infections Caused By Herpes Simplex Virus (HSV) And Varicella-Zoster Vir
StrengthAcyclovir (200mg, 400mg, 800mg) Tablets
FormTablets
Brand NameAcyclovir (200mg
TypeTablets
Acyclovir (200mg, 400mg, 800mg) Tablets
Category:
Antiviral
Antiherpetic Agent
Uses:
Treatment and suppression of infections caused by Herpes Simplex Virus (HSV) and Varicella-Zoster Virus (VZV)
Genital herpes (initial and recurrent episodes)
Herpes labialis (cold sores)
Herpes zoster (shingles)
Varicella (chickenpox)
Prophylaxis in immunocompromised patients (HIV, transplant)
Mechanism of Action:
Acyclovir is a guanosine analogue that gets converted into its active form (acyclovir triphosphate) by viral thymidine kinase. It inhibits viral DNA polymerase, preventing viral DNA synthesis, leading to inhibition of viral replication.
Dosage:
IndicationTypical Adult Dosage
Genital Herpes (Initial)
200mg 5 times daily or 400mg 3 times daily for 7–10 days
Genital Herpes (Recurrent)
200mg 5 times daily for 5 days or 800mg twice daily for 5 days
Suppressive therapy
400mg twice daily
Herpes Zoster (Shingles)
800mg 5 times daily for 7–10 days
Chickenpox
800mg 4 times daily for 5 days
Immunocompromised patients
Dose may vary, often higher and longer duration
Common Side Effects:
Nausea
Diarrhea
Headache
Abdominal pain
Fatigue
Skin rash
Dizziness
Serious Side Effects:
Acute kidney injury (rare, especially with IV form)
Neurotoxicity (confusion, agitation, hallucinations)
Blood dyscrasias (rare)
Precautions:
Maintain adequate hydration to prevent renal complications
Adjust dose in renal impairment
Use with caution in elderly and dehydrated patients
Contraindications:
Hypersensitivity to acyclovir or related antivirals (valacyclovir, famciclovir)
Counseling Tips:
Take with a full glass of water
Complete the full course even if symptoms improve early
Use protection during sexual activity (herpes can still transmit during treatment)
Inform doctor if you experience unusual tiredness, confusion, or skin reactions
Storage:
Store at room temperature (15°C–25°C)
Protect from moisture
Keep out of reach of children
Post Free Ad
www